Product Code: 200065793

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Hubei,China

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Chemical Products,Chemical reagent,additive,raw material of food,Packaging Materials,Pharmaceutical intermediate

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Di-tert-butyl dicarbonate
  • FOB Price
    US $ 15.00 - 20.00 / Kilogram(s)
  • Min. Order
    1 Kilogram(s)
  • Payment Terms
    T/T, Western Union
  • Port
    Optional
  • Delivery Time
    3 days after payment
  • CAS No.:
    24424-99-5
  • Other Names:
    Pyrocarbonic Acid Di-...
  • MF:
    C10H18O5
  • EINECS No.:
    246-240-1
  • Place of Origin:
    china
  • Grade Standard:
    Industrial Grade,Food...
  • Purity:
    99%
  • Appearance:
    liquid
  • Application:
    Amino protecting agen...
  • Brand Name:
    Hong Chengming
  • Model Number:
    he4582
  • PSA:
    61.83000
  • logP:
    2.87320
Product Description

Di-tert-butyl dicarbonate Basic information
Product Name:Di-tert-butyl dicarbonate
Synonyms:(BOC)2O;(BOC)2O FLUKA;BOC;BOC ANHYDRIDE;DI-T-BUTYL DICARBONATE;DI-T-BUTYL PYROCARBONATE;DI-TERT-BUTYL PYROCARBONATE;DI-TERT-BUTYL DICARBONATE
CAS:24424-99-5
MF:C10H18O5
MW:218.25
EINECS:246-240-1
Product Categories:Amino Acid Derivatives;Starting Raw Materials & Intermediates;Organics;N-Protecting Reagents;Biochemistry;Peptide Synthesis;Protection & Derivatization Reagents (for Synthesis);Protective Reagents (Peptide Synthesis);Reagents for Oligosaccharide Synthesis;Synthetic Organic Chemistry;Boc-Amino acid series;Miscellaneous Reagents;Pharmaceutical Intermediates
Mol File:24424-99-5.mol
Di-tert-butyl dicarbonate Structure

Di-tert-butyl dicarbonate Chemical Properties
Melting point 23 °C(lit.)
Boiling point 65-67 °C
density 0.95 g/mL at 25 °C(lit.)
refractive index n20/D 1.409(lit.)
Fp 99 °F
storage temp. 2-8°C
form Low Melting Crystalline Solid
color White
Water Solubility Miscible with decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile and dimethylformamide. Immiscible with water.
Sensitive Moisture Sensitive
BRN 1911173
InChIKeyDYHSDKLCOJIUFX-UHFFFAOYSA-N
CAS DataBase Reference24424-99-5(CAS DataBase Reference)
EPA Substance Registry SystemDicarbonic acid, bis(1,1-dimethylethyl) ester(24424-99-5)

Safety Information
Hazard Codes T+,T,F,Xi,F+
Risk Statements 11-19-26-36/37/38-43-10-40
Safety Statements 16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
RIDADR UN 2929 6.1/PG 1
WGK Germany 3
RTECS HT0230000
4.4-10-21
Hazard Note Flammable/Irritant/Very Toxic
TSCA Yes
HazardClass 6.1
PackingGroup I
HS Code 29209010
MSDS Information
ProviderLanguage
Di-tert-butyl dicarbonateEnglish
SigmaAldrichEnglish
ACROSEnglish
ALFAEnglish

Di-tert-butyl dicarbonate Usage And Synthesis
Chemical PropertiesWhite to off-white microcrystalline powder
UsesReagent commonly used in organic chemistry for the introduction of the BOC protecting group.
Usesreagent for t-BOC-protected amines
UsesReagent for the preparation of Boc-amino acids and peptides in high yields.
Purification MethodsMelt the ester by heating at ~35o, and distil it in a vacuum. If IR and NMR ( 1810m 1765 cm-1 , in CCl4 1.50 singlet) suggest very max impure, then wash with an equal volume of H2O containing citric acid to make the aqueous layer slightly acidic, collect the organic layer and dry it over anhydrous MgSO4 and distil it in a vacuum. [Pope et al. Org Synth 57 45 1977, Keller et al. Org Synth 63 160 1985, Grehn et al. Angew Chem 97 519 1985.] FLAMMABLE.

Di-tert-butyl dicarbonate Preparation Products And Raw materials
Preparation ProductsN-Boc-D-proline-->BOC-L-Isoleucine -->5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE-->TERT-BUTYL 4-(5-FORMYL-4-METHYL-1,3-THIAZOL-2-YL)PIPERIDINE-1-CARBOXYLATE-->1-Boc-4-cyanopiperidine-->TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE-->6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID-->1-TERT-BUTYL 6-METHYL 3-FORMYL-1H-INDOLE-1,6-DICARBOXYLATE-->(S)-N-Boc-allylglycine-->TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE-->2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID-->1-Boc-piperazine-->Spermidine-->TERT-BUTYL 3-(4-AMINO-2,6-DICHLOROPHENOXY)PROPYLCARBAMATE-->3-TERT-BUTOXYCARBONYLAMINO-ISONICOTINIC ACID-->6-BOC-HYDRAZINONICOTINIC ACID-->4-BOCAMINO-NICOTINIC ACID-->(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine-->(R)-PIPERAZINE-2-CARBOXYLIC ACID-->(3-HYDROXYMETHYL-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER-->6-(BOC-AMINO)-HEXYL BROMIDE-->N-1-BOC-N-4-CBZ-2-PIPERAZINECARBOXYLIC ACID T-BUTYL ESTER-->4-ALLYL-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER-->1-BOC-PIPERAZINE-->TERT-BUTYL 4-(HYDROXYMETHYL)PYRIDIN-2-YLCARBAMATE-->1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE-->(S)-(-)-1-Boc-2-pyrrolidinemethanol-->TERT-BUTYL 4-FORMYL-2-METHOXYPHENYL CARB ONATE, 99-->3-[(N-(TERT-BUTYLOXYCARBONYL)AMINO)METHYL]PYRIDINE-->tert-Butyl N-(2-bromoethyl)carbamate-->N-Boc-N,N-bis(2-chloroethyl)amine-->4-CHLORO-(N-BOC)ANILINE 97-->TERT-BUTYL N-(2-HYDROXYETHYL)CARBAMATE-->4-(BOC-AMINOMETHYL)PYRIDINE-->N-BOC-piperidine-4-carboxylic acid-->1-(4-PYRIDYLMETHYL)PIPERAZINE-->N,N-DIMETHYL-2-PIPERAZIN-1-YL-ACETAMIDE-->1-Boc-3-oxopiperazine-->TERT-BUTYL 4-(METHOXYCARBONYL)PYRIDIN-2-YLCARBAMATE
Raw materialsTetrahydrofuran-->Carbon tetrachloride-->CARBON DIOXIDE-->Potassium tert-butanolate-->1,8-Diazabicyclo[5.4.0]undec-7-ene-->N-OCTANE