Natural Female Hair Loss Treatment Powder , DapoxetineOral Male Sex Hormone For PE Treatment
Product Name: Dapoxetine
MF: C21H23NO. HCl
Storage: Ventilation low temperaturedrying
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Dapoxetine, marketed as Priligy (among and other brands)is the first compound developed specially for the treatment of prematureejaculation (PE) in men 18–64 years old.Dapoxetine works by inhibiting theserotonin transporter, increasing serotonin's action at the post synaptic cleft,and as a consequence promoting ejaculatory delay. As a member of selectiveserotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created asan antidepressant. However, unlike other SSRIs, dapoxetine is absorbed andeliminated rapidly in the body. Its fast acting property makes it suitable forthe treatment of PE but not as an antidepressant.
Dapoxetine is a white powder substance andwater-soluble. Taken 1–3 hours before sexual activity, it is rapidly absorbed inthe body. Its maximum plasma concentration (Cm) is reached 1–2 hours after oraladministration.
Randomized, double blind, placebo-controlled trials haveconfirmed the efficacy of dapoxetine for the treatment of PE.Different dosagehas different impacts on different type of PE. Dapoxetine 60 mg significantlyimproves the mean intravaginal ejaculation latency time (IELT) compared to thatof dapoxetine 30 mg in men with lifelong PE, but there is no difference in menwith acquired PE. Dapoxetine, given 1–3 hours before sexual episode, prolongsIELT, increases the sense of control and sexual satisfaction in men of 18 to 64years of age with PE. Since PE is associated with personal distress,interrelationship difficulty, dapoxetine provides help for men with PE toovercome this condition. Because lack of specific approval treatment for PE inthe US and some other countries, other SSRIs such as fluoxetine, paroxetine,sertraline, fluvoxamine, and citalopram have been used as off label drugs totreat PE.
Waldinger's meta analysis shows that the use of theseconventional antidepressants increasing IELT from two to ninefold above baseline in comparison of three to eightfold when dapoxetine is used.However, theseSSRIs must be taken daily in order to achieve meaningful efficacy, and the longhalf-life increases the risk of the drug accumulation and as a consequenceincreased of adverse effects such as decreasing sexual libido and causingerectile dysfunction. Dapoxetine, on the other hand, is a fast-acting SSRI.It is rapidly absorbed and eliminated from the body within a few hours. Thisfavorable pharmacokinetics minimizes the risk of the drug's accumulation in thebody, and therefore reducing side effects.
White or almost whitecrystalline powder
Loss on drying
It complies to prescrlbedenterprise standard
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